Whitepaper , Modified Release , Formulation Development , Translational Pharmaceutics

Alternative Strategies for Development of Modified Release Dosage Forms

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Overview

Modified-release (MR) formulations are in high demand in today's drug development strategies.

For formulators, they enable drugs to be released in the optimal gastrointestinal (GI) locations to achieve and maintain desirable plasma concentrations for extended periods, avoiding undesirable excursions outside the therapeutic range.

Learn more about our capabilities for modified-release.

 

Types of modified-release dosage forms we work with:

Modified-release formatObjectiveFormulation technology
Gastro-retention
  • Keep the formulation in the stomach for an extended period to maximize the duration of absorption or therapeutic activity
Swellable tablets (monolithic, bilayer, trilayer)
Gastro-resistant
  • Prevent release of the drug in the stomach and/or upper gastrointestinal (GI) tract
  • Overcome first-pass metabolism or gastric irritation
Enteric-coated tablets or capsules
Sustained or extended release
  • Extend the in-vivo release profile of the drug or enable once-daily dosing
Matrix tablets, coated tablets, or multiparticulates
Targeted or controlled delivery
  • Release the drug at or near the intended site of absorption or action
  • Have either immediate-release or extended-release characteristics
  • Deliver time-, pH-, or microbially-triggered release
Tablets, capsules, or multiparticulates
Biphasic release
  • Eliminate the need for repeat dosing
  • Provide rapid therapeutic effect from an immediate-release layer and extended dosing from a sustained-release layer
Bilayer tablets or multiparticulates
Pulsatile release
  • Release the drug as a pulse after a pre-determined lag time, designed according to the body’s circadian rhythm
  • Provide a release mechanism beneficial for drugs where time-dependent dosing is required or those that undergo first-pass metabolism
Bilayer tablets or multiparticulates
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