Senior Solid State Chemist

Senior Solid State Chemist

Company Overview

Quotient Sciences is a drug development and manufacturing accelerator providing integrated programs and tailored services across the entire development pathway. Cutting through silos across a range of drug development capabilities, we save precious time and money in getting drugs to patients.

As a growing and successful business, we employ more than 1,100 talented individuals globally, located at state-of-the-art development, manufacturing and clinical facilities in the UK and USA.

Science, Agility and Culture are the core components that define Quotient Sciences, enabling us to do what we do in the way that we do it. People join Quotient Sciences because we are a respected member of the drug development community, driven by an unswerving belief that ideas need to become solutions, and molecules need to become cures, fast. Because humanity needs solutions, fast.

The Role

We are seeking a highly motivated and experienced Solid State Chemist to join our Drug Substance and Translational Pharmaceutics team. The successful applicant will be responsible for developing and characterising solid state forms of drug substance (API) and key intermediates as well as providing support the Process Research and Development, Formulation Development and Analytical teams.

You will design, perform and manage experiments to prepare and characterise solid state forms of drug substance, including salt, cocrystal, polymorphic and amorphous forms.   

You will communicate results to clients and other stakeholders and provide mentoring and supervision to more junior colleagues.

Key Tasks:

• Prepare and characterise novel solid state forms of dug substance
• Conduct analysis and interpretation of the resulting data to characterise solid-state properties of drug substance and intermediates using techniques such as NMR, XRPD, DSC, DVS, FTIR, optical microscopy, TGA and KF
• Determination of and development of strategies to control particle size of drug substance
• Prepare data packages on chemical entities so that their identity can be considered to be conclusively established
• Provide verbal and written updates to clients and other stakeholders.
• Provide consultancy to the synthetic chemistry teams on crystallisation methodologies to enhance impurity rejection and provide control of solid state properties
• Work compliantly with due regard to regulatory, environmental and health and safety procedures.

The Candidate

The successful candidate will have good knowledge of and experience in solid state chemistry, including the preparation and characterisation of novel salt and polymorphic forms of drug substance. You will have excellent communication skills and work well within a cross functional project team.

Other skills and experience required:

• Good written and oral communication skills.  
• Good understanding of process safety and hazard operability.
• Either a MSc (or equivalent) or PhD qualification in chemistry or a closely related discipline, with a minimum of four or two year’s relevant industrial experience respectively. 

Company benefits:

In return, you will receive a competitive salary, a generous benefits package, excellent training and development, as well as an exciting career within a fast paced and dynamic business. 

Our commitment to Diversity & Inclusion

Quotient Sciences business are advocates for positive change and conscious inclusion. We strive to create a diverse Quotient family by remaining committed to the development of our culture, equality, mindset, diversity & inclusions in the workplace.

As a global employer, we recognise the value in having an organisation that is a true reflection and representation of our society today. All applicants welcome.